|Human Jagged 1/JAG1 Protein
分子别名（Synonyms）Jagged1; hJ1; CD339; JAGL1; AGS; AHD; AWS
货号：JAG-HE101
产品信息（Product Information）
表达区间及表达系统（Source） | Recombinant Human Jagged 1/JAG1 Protein is expressed from HEK293 with His tag at the C-Terminus. |
分子量大小（Molecular Weight） | The protein has a predicted MW of 111.56 kDa. Due to glycosylation, the protein migrates to 120-140 kDa based on Bis-Tris PAGE result. |
纯度（Purity） | > 95% as determined by Bis-Tris PAGE |
内毒素（Endotoxin） | Less than 1EU per μg by the LAL method. |
制剂（Formulation） | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
重构方法（Reconstitution） | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
存储（Storage） | -20 to -80°C for 12 months as supplied from date of receipt. |
产品数据（Assay Data）
Bis-Tris PAGE
Human Jagged 1 on Bis-Tris PAGE under reducedcondition. The purity is greater than 95%.
背景（Background）
JAGGED1 (JAG1) is composed of a relatively small intracellular domain, a transmembrane domain and a larger extracellular component. JAG1 is widely expressed throughout mammalian development, across many tissues and developmental stages. The Notch signaling pathway and JAG1 in particular have been implicated in multiple forms of cancer and multiple aspects of cancer biology including tumor angiogenesis, neoplastic cell growth, cancer stem cell maintenance and the metastatic process.
文献（References）
Grochowski CM, Loomes KM, Spinner NB. Jagged1 (JAG1): Structure, expression, and disease associations. Gene. 2016 Jan 15;576(1 Pt 3):381-4. doi: 10.1016/j.gene.2015.10.065. Epub 2015 Nov 6. PMID: 26548814; PMCID: PMC4673022.
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