|Human FGF7/KGF Protein
分子别名（Synonyms）FGF-7; HBGF-7; KGF; FGF7
产品信息（Product Information）
表达区间及表达系统（Source） | Recombinant Human FGF-7/KGF Protein is expressed from E.coli without tag. |
分子量大小（Molecular Weight） | The protein has a predicted MW of 18.88 kDa same as Bis-Tris PAGE result. |
纯度（Purity） | > 95% as determined by Bis-Tris PAGE |
内毒素（Endotoxin） | Less than 0.1EU per μg by the LAL method. |
制剂（Formulation） | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). |
重构方法（Reconstitution） | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. |
存储（Storage） | -20 to -80°C for 12 months as supplied from date of receipt. |
产品数据（Assay Data）
Bis-Tris PAGE
Human FGF-7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
ELISA Data
Immobilized Human FGF-7, No Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human FGFR2 beta (IIIb), hFc Tag with the EC50 of 0.87 μg/ml determined by ELISA.
背景（Background）
The expression patterns of mRNAs encoding Fibroblast Growth Factor-7 (FGF-7) and its high affinity receptor suggested that FGF-7 signaling may play a role in regulating ureteric bud growth.t Results of these studies demonstrate that the developing ureteric bud and mature collecting system of FGF-7-null kidneys is markedly smaller than wild type. FGF-7 levels modulate the extent of ureteric bud growth during development and the number of nephrons that eventually form in the kidney.
文献（References）
Qiao J, Uzzo R, Obara-Ishihara T, Degenstein L, Fuchs E, Herzlinger D. FGF-7 modulates ureteric bud growth and nephron number in the developing kidney. Development. 1999 Feb;126(3):547-54. PMID: 9876183.
